Adoptive Immunotherapy with Antigen-Specific T Cells Expressing a Native TCR
نویسندگان
چکیده
منابع مشابه
Antigen-specific T cells conditioned with MDSC display a surprising increased anti-tumor activity after adoptive T cell-based immunotherapy
The success of adoptive T cell-based immunotherapy (ACT) in cancer is limited in part by the accumulation of myeloid-derived suppressor cells (MDSC), which block several T cell functions, including proliferation and expression of effector mediators. Paradoxically, inhibition of CD8 T cell differentiation during the preACT phase also showed to increase anti-tumor efficacy. Thus, we aimed to dete...
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ژورنال
عنوان ژورنال: Cancer Immunology Research
سال: 2019
ISSN: 2326-6066,2326-6074
DOI: 10.1158/2326-6066.cir-18-0888